Cold & Flu Treatment Over the Counter Overdosing on Cold and Flu Medications By Kristina Herndon, RN Updated on December 13, 2023 Medically reviewed by Anju Goel, MD Print Table of Contents View All Table of Contents Accidental Causes Signs of Overdose Medication Abuse Signs of Abuse Over-the-counter (OTC) cough and cold medicines are widely available, low-cost, and can help relieve some symptoms of upper respiratory infections and the flu. While they have some benefits, these medications carry a risk of overdosing. Overdosing of OTC cold and flu remedies is often accidental—due to errors like misreading product labels or dosing. Sometimes, these medications are also intentionally abused. Signs of overdose include excessive fatigue or dizziness, sudden jitteriness, confusion, and more. This article discusses intentional and accidental overdoses of cold and flu medicines, as well as signs of overdose and medication abuse. How to Choose the Best Over-the-Counter Cough Medicine SB / Getty Images How an Accidental Overdose Happens Overconsumption of drugs found in cold and flu remedies poses health risks. These drugs include: Acetaminophen: relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause pain and fever Non-steroidal anti-inflammatories (NSAIDs): relieve pain and reduce fever and inflammation Dextromethorphan: a cough suppressant that works in the part of your brain that makes you cough, telling your body to cough less Pseudoephedrine: relieves nasal congestion by reducing swelling in the sinuses to help mucus and air flow more freely Antihistamines: block a chemical called histamine that causes symptoms such as sneezing, itchy eyes, and postnasal drip Using these medications with alcohol can also lead to overdosing. There are several reasons that accidental overdoses can happen with cold and flu medications, including: Ignoring dosing recommendations and taking whatever dose is desiredTaking more frequent doses to try to overcome an illness fasterMisreading a product labelMeasuring the dose incorrectly Taking different OTC cold and flu remedies can cause an overdose if they contain some of the same ingredients. For example, if you were to take a multi-symptom medication like NyQuil along with Tylenol (or Tylenol Extra Strength) for fever and pain, you could overdose on acetaminophen, which is in both products. Taking too much acetaminophen can potentially cause liver damage. This risk is even higher with alcohol. According to research published in the Journal of Clinical and Translational Hepatology, acetaminophen overdose accounts for more than 50% of overdose-related acute liver failures in the United States. Preventing Overdose Ways to avoid these mistakes include: Reading the product labelsAvoiding co-administration of remedies with the same ingredientsLimiting yourself to the recommended doseAbstaining from alcohol when taking cold and flu medications Can You Overdose on Nyquil? Nyquil Cold and Flu is a combination medication containing acetaminophen, dextromethorphan, and doxylamine. Overdose side effects can include drowsiness, blurred vision, upset stomach, nervousness, or more serious side effects such as confusion, hallucinations, trouble urinating, and irregular heartbeat.Do not take more than four doses in 24 hours. See the directions on the box for the correct dosage for adults and children.Nyquil should not be used as a sleep aid. A 2015 review concluded there weren’t enough quality studies to determine its safety or effectiveness as a sleep aid. How Cold and Flu Are Treated Signs of Accidental Overdose Though you may never anticipate a cold and flu medication overdose, they can easily happen. It's important to recognize the signs of an OTC cold and flu medication including: Excessive tiredness or lethargyExtreme dizziness or drowsinessSudden anxiety or jitterinessConfusionAbdominal painLabored or shallow breathingLoss of appetiteNausea or vomitingRapid heart rateBlurred visionDilated pupilsDark-colored urineUnresponsivenessness In cases of overdose, get emergency medical help or call Poison Control at 1-800-222-1222. It's important to get immediate medical care, even if you don't notice any symptoms yet. How to Treat Cold and Flu in Children Abuse of Cold/Flu Medication Several different ingredients in cold, cough, and flu medications can be abused. Dextromethorphan (DMX) Some people abuse OTC cold, cough, and flu remedies containing dextromethorphan (DMX). These products are readily available throughout the United States in syrup, tablet, and powder form. Brands of cough medications containing DMX include: Delsym 12-hour CoughRobitussin Cough Long-ActingTriaminic Long-Acting CoughVicks DayQuil Cough There are over 50 brands of combination products (such as cough and cold, or flu) medications for both adults and children that contain DMX. Some examples include: Alka-Seltzer Plus Cold and Cough FormulaChildren's Dimetapp Multisymptom Cold and FluChildren's Mucinex CoughChildren's Robitussin Cough and Cold CFCoricidin HBP Day and Night Multi-Symptom ColdDiabetic Tussin DMPediaCare Children's Fever Reducer Plus Cough and Runny NoseSudafed PE Day/Night ColdTheraflu Cold and CoughTriaminic Cough and Sore ThroatTylenol Cold and Cough DaytimeVicks Children's NyQuil Cold and Cough The abuse of DMX is most common among 8th to 12th graders. When swallowed or snorted in excess, DMX can cause hallucinogenic effects similar to the anesthetic drug ketamine or the street drug phencyclidine (also known as PCP or "angel dust.") Depending on how much is taken, the effects can last for as long as six hours or even more. The overuse of DMX is associated with an array of side effects, including: A feeling of floatingConfusion and disorientationImpaired judgmentBlurred visionLoss of coordinationSlurred speechDizzinessExcessive sweatingHyperactivityHallucinationsRapid or pounding heartbeatsA drop in body temperatureHot flashesDiarrheaAbdominal painNausea and vomitingUnconsciousness Repeated abuse of DXM at high doses can also cause a condition known as chemical psychosis in which a person loses touch with reality. Referred to by some as "poor man's psychosis," the DMX-induced disorder (characterized by paranoia, delusions, hallucinations, and disassociation) has been known to lead to impulsive and even violent acts, including assault and self-harm. An overdose of DMX can lead to more serious symptoms, including seizures, cerebral hemorrhage (bleeding in the brain), permanent brain damage, and even death. To prevent abuse in your family, educate your kids about the dangers of DMX, monitor their activities, keep track of all cold and flu medications in the home, and avoid stockpiling medications containing DMX. Alcohol Alcohol used to be a common ingredient in many OTC cough syrups. As a public safety measure, alcohol is no longer a component of most OTC remedies. However, some cold and flu combination medications such as NyQuil and Theraflu still contain alcohol. Because fewer remedies contain alcohol, there is less of a concern for abuse. Codeine Codeine has also been an ingredient in many OTC cough syrups that were abused. As a public health safety measure, codeine has been classified as a controlled substance. Products containing 90 mg or more of codeine, like Tylenol 3, are Schedule III controlled substances and require a prescription to use them. Types of Psychosis Signs of Abuse Since DMX abuse is largely hidden, it is important to recognize the signs of overdose. If you suspect that someone has overdosed on DMX, call 911 if there are any of the following symptoms: Extreme disorientation or drowsinessBlueish lips, fingernails, or skinVomitingSeizuresVery slow or very rapid heartbeatsSlow, shallow, or labored breathingUnconsciousnessNo breathing Until help arrives, call Poison Control 1-800-222-1222 for instructions on what to do. Summary While OTC cold, cough, and flu medicines have some benefits, they also carry a risk of overdosing, which can be accidental or intentional. If you're self-treating a cold, carefully read and follow product instructions and only treat the symptoms you have. Know the signs of medication overdose and abuse to be able to get someone help if needed. 8 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Spangler DC, Loyd CM, Skor EE. Dextromethorphan: a case study on addressing abuse of a safe and effective drug. Subst Abuse Treat Prev Policy. 2016;11(1):22. doi:10.1186/s13011-016-0067-0 Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: A comprehensive update. J Clin Transl Hepatol. 2016;4(2):131-42. doi:10.14218/JCTH.2015.00052 U. S. National Library of Medicine. DailyMed. Vicks NyQuil Cold and Flu Nighttime Relief. Culpepper L, Wingertzahn MA. 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