What You Need to Know About DayQuil

Effectiveness and Considerations

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DayQuil Cold & Flu is a multi-purpose medication used to treat common cold and flu symptoms. It is the daytime equivalent of NyQuil, designed to provide temporary symptom relief without making you drowsy.

DayQuil ingredients include a fever and pain reducer (acetaminophen), cough suppressant (dextromethorphan), and decongestant (phenylephrine). The medicine comes in a gel cap and liquid formulas.

This article discusses DayQuil ingredients. It also explains how to take DayQuil, its potential side effects, and its interactions.

DayQuil Severe and NyQuil Severe brand cold and flu medicine.

Bloomberg / Getty Images

DayQuil Ingredients

DayQuil is available in either a gel cap or syrup formulation. Both are orange-colored (in contrast to their nighttime counterpart, NyQuil, which is green). The syrup has a sweetened orange flavor with an antiseptic aftertaste.

DayQuil (regular strength) contains the following three active ingredients per 15-milliliter (mL) dose:

Different formulations of DayQuil may contain different ingredients.

Phenylephrine Effectiveness

In 2023, a Food and Drug Administration advisory panel concluded that phenylephrine isn't effective as a decongestant when taken orally. For now, however, it's still included in Dayquil and similar products.

Inactive Ingredients

The inactive ingredients in DayQuil include:

  • FD&C Red No. 40
  • FD&C Yellow No. 6
  • Gelatin
  • Glycerin
  • Polyethylene glycol
  • Povidone
  • Propylene glycol
  • Purified water
  • Sorbitol special
  • Titanium dioxide

Again, inactive ingredients may differ based on the specific formulation.

Does DayQuil Have Caffeine in It?

No, DayQuil does not contain caffeine, making it a suitable choice for people who are sensitive to caffeine.

Recommended Dosage of DayQuil

The dosage of DayQuil varies by formulation. For the standard syrup formulation, the recommended dosage is as follows:

  • Adults and children over 12: 2 tablespoons (30 ml) every four hours with no more than six doses per 24 hours
  • Children ages six to 12: 1 tablespoon (15 ml) every four hours with no more than five doses per 24 hours

DayQuil should not be used in children under the age of 6 unless under the direction of a pediatrician.

Can I Take DayQuil at Night?

Yes, taking DayQuil at night shouldn't keep you awake. One of the active ingredients in DayQuil is a mild stimulant called phenylephrine. However, DayQuil contains just 5 mg of phenylephrine, whereas the stimulating effects of phenylephrine tend to start at doses of 10 to 15 mg.

Side Effects and Considerations

While DayQuil is considered safe if used as directed, it can cause nervousness, dizziness, or sleepiness in some and should be avoided in the following circumstances:

  • DayQuil can cause liver damage in people who drink more than three alcoholic beverages per day. Do not take DayQuil with other medications containing acetaminophen. Taking excessive acetaminophen may cause liver damage even in non-drinkers.
  • Do not take DayQuil if you are taking monoamine oxidase inhibitors (MAOIs) or have taken one in the past two weeks. MAOIs are a class of drugs used to treat depression, anxiety, and other mood disorders.
  • You should stop taking DayQuil and call your healthcare provider if your cold or flu symptoms worsen, last for more than seven days, or are accompanied by a fever lasting for more than three days. The same rules apply to children if the cold or flu symptoms last more than five days.

Drug Effectiveness of DayQuil

While the acetaminophen component of DayQuil is effective in treating cold symptoms such as headache and fever, several studies have found that ibuprofen is superior to acetaminophen for relieving pain.

Acetaminophen is better known by the brand name Tylenol. Ibuprofen, meanwhile, is marketed under the brand names Advil and Motrin, among others.

In terms of cough relief, the jury remains largely split. Some research shows that OTC cough formulations, including DayQuil, provide no better or worse relief than receiving no treatment at all. On the other hand, there is also evidence that dextromethorphan, one of the active ingredients in DayQuil, may be the most effective cough suppressant available after all.

Summary

DayQuil Cold and Flu is a multi-purpose medication used to treat cold and flu symptoms. It contains three active ingredients: the pain-reliever acetaminophen, the cough suppressant dextromethorpan, and the decongestant phenylephrine.

DayQuil is considered safe when used as direction, but it does come with a potential for side effects in some people, such as nervousness, dizziness, and sleepiness. If your symptoms last more than seven days despite taking DayQuil, stop taking the drug and contact your healthcare provider.

Frequently Asked Questions

  • How often can you take DayQuil?

    You can take DayQuil every four hours, with no more than six doses in 24 hours.

  • Will DayQuil make you tired?

    Even though it is marketed for daytime use, some people who take DayQuil report it makes them tired. Common side effects of DayQuil include nervousness, dizziness, or sleepiness.

  • How long does it take for DayQuil to kick in?

    It varies from person to person, but DayQuil typically starts to work to relieve symptoms in about 30 minutes.

  • Can I take DayQuil and ibuprofen?

    Yes, you can take DayQuil and ibuprofen together, but you may want to spread out the doses to provide longer symptom relief.

  • Can I take DayQuil and Tylenol?

    No, you should not take DayQuil and Tylenol together. Dayquil contains acetaminophen, which is the same medicine as Tylenol. Taking more than the recommended maximum of 3,000 mg a day can cause liver damage.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Food and Drug Administration. FDA clarifies results of recent advisory committee meeting on oral phenylephrine.

  2. Vicks. DayQuil FAQs.

  3. Atkinson H, Potts A, Anderson B. Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review. Eur J Clin Pharmacol. 2015 May;71(8):931-938. doi:10.1007/s00228-015-1876-1

  4. Moore RA, Derry S, Wiffen PJ, Straube S, Aldington DJ. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015 Oct;19(9):1213-1223. doi:10.1002/ejp.649

  5. Morice A, Kardos P. Comprehensive evidence-based review on European antitussives. BMJ Open Resp Res. 2016;3(1):e000137. doi:10.1136/bmjresp-2016-000137

By Kristina Herndon, RN
Kristina Herndon, BSN, RN, CPN, has been working in healthcare since 2002. She specializes in pediatrics and disease and infection prevention.